Table 1.
Applied schemes for tapering long-term antidepressant usage in primary care
|
Antidepressant |
AD tapering scheme (steps per 2 weeks, dose in mg/day) |
||||
|---|---|---|---|---|---|
| Start dose | Step 1 | Step 2 | Step 3 | Step 4 | |
|
TCA |
|
|
|
|
|
| · Amitriptyline |
> 150 |
150 |
100 |
50 |
25 |
| · Imipramine |
> 150 |
150 |
100 |
50 |
25 |
| · Nortriptyline |
> 150 |
150 |
100 |
50 |
25 |
| · Clomipramine |
> 150 |
150 |
100 |
50 |
25 |
|
SSRI |
|
|
|
|
|
| · Fluoxetine |
> 60 |
40 |
30 |
20 |
10 |
| · Paroxetine |
> 40 |
40 |
30 |
20 |
10 |
| · Sertraline |
> 150 |
150 |
100 |
50 |
25 |
| · Citalopram |
> 40 |
40 |
30 |
20 |
10 |
| · Escitalopram |
> 20 |
20 |
15 |
10 |
5 |
| · Fluvoxamine |
> 150 |
150 |
100 |
50 |
25 |
|
Other antidepressants |
|
|
|
|
|
| · Mirtazapine |
> 45 |
45 |
30 |
15 |
- |
| · Duloxetine |
> 120 |
120 |
90 |
60 |
30 |
| · Venlafaxine |
> 150 |
150 |
112.5 |
75 |
37.5 |
| · Trazodon | > 150 | 150 | 100 | 50 | - |