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. 2013 Jan 14;8(1):e53994. doi: 10.1371/journal.pone.0053994

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© 2013 Gajiwala et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Allosteric activation via (A) symmetric dimerization of Ack1, (B) asymmetric dimerization of EGFR and (C) heterodimerization of CDK2-cyclinA. Backbone trace of each molecule of the dimeric complex is drawn, highlighting the αC helix of each kinase domain in cyan and the activation loop in blue. Molecule A of each kinase domain is shown in magenta and molecule B (cyclin in case of CDK2) in gray. For clarity, the secondary structure of only the N-terminal lobe is displayed.