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Hydroxyprogesterone formation during whole-cell conversion in bioreactor. Time course of hydroxyprogesterone formation during whole-cell conversion of progesterone by Y. lipolytica YL22 cells harboring CYP3A4 and hCPR. Closed triangles: aqueous phase system; open circles: with dibutylphthalate (DBP) as second organic phase; open squares: with ethyl oleate as second organic phase.
