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. 2012 Nov 13;8:83. doi: 10.1186/1744-8069-8-83

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Copyright ©2012 Busch-Dienstfertig et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CRF-induced antinociception in recipients of activated, ConA/IL-4-stimulated T cells is opioid mediated.A) NLX reversibility of CRF-induced antinociception in CTX-treated recipients of T cells stimulated with ConA/IL-4. PPT were determined at baseline and after i.pl. injections of T cells and CRF. Controls received s.c. NaCl. B) CRF-induced antinociception and NLX-reversibility in non-immunosuppressed rats. PPT were determined at baseline and after CRF injection. Data represent means ± SD (n = 7–8 animals per group). Effects of the injection (baseline versus CRF) and of the treatment (saline versus NLX) on ipsilateral PPT were analyzed using Two-Way RM ANOVA and Bonferroni’s Test. §§§, CRF injection significantly elevated PPT in NaCl-treated animals (P < 0.001); ***, CRF-induced elevation of PPT is significantly reduced by NLX (P < 0.001).