Table 1. Laminin-111-derived peptides active with tumor cells, sequence, location and activity.
Peptide/location residues | Activity | Receptor |
---|---|---|
YIGSR/β1 929–933 |
↑ adhesion, ↑ migration, ↓ tumor growth, ↓ metastasis, ↓ invasion |
67 kD protein |
IKVAV/α1 2097–2108 |
↑ metastasis, ↑ tumor growth, ↑ angiogenesis, ↑ proteases |
integrins α3β1, α6β1 |
RKRLQVQLSIRT (AG73)/α2620–2631 |
↑ tumor growth, ↑ metastasis to lung, bone and liver, ↑ invasion, ↑ angiogenesis, ↑ proteases |
syndecans 1, 2 and 4 |
KAFDITYVRLKF (C16)/γ1 139–150 | ↑ metastasis, ↑ angiogenesis | integrins αvβ3, α5β1 |