Table 2.
Fatty streak lesion areas, plasma cholesterol levels, and fasting plasma insulin levels in Mbc-Ldlr0 mice grouped by genotype at D4Mit127
| Genotype | Lesion area, μm2/section | Total C, mg/dl | HDL-C, mg/dl | Non-HDL-C, mg/dl | Insulin, ng/ml |
|---|---|---|---|---|---|
| Females | |||||
| BB (n = 32) | 3.6 ± 1.8 × 105 | 344 ± 43 | 51 ± 13 | 295 ± 47 | 1.32 ± 1.0 (n = 15) |
| MB (n = 40) | 6.1 ± 2.0 × 105* | 341 ± 55 | 59 ± 16** | 284 ± 52 | 1.06 ± 0.67 (n = 7) |
| Males | |||||
| BB (n = 39) | 3.6 ± 2.2 × 105 | 384 ± 57 | 71 ± 17 | 311 ± 59 | 3.16 ± 1.66 (n = 27) |
| MB (n = 48) | 3.6 ± 2.0 × 105 | 366 ± 56 | 75 ± 15 | 291 ± 54 | 3.66 ± 2.61 (n = 10) |
BB, homozygous for C57BL/6J alleles; MB, heterozygous for C57BL/6J and MOLF alleles.
*
, P < 0.0001 vs. BB;
**
, P < 0.03 vs. BB. Values are mean ± SD.