Table 3.
Fatty streak lesion areas, plasma cholesterol levels, and fasting plasma insulin levels in Mbc-Ldlr0 mice grouped by genotype at D6Mit110
| Genotype | Lesion area, μm2/section | Total C, mg/dl | HDL-C, mg/dl | Non-HDL-C, mg/dl | Insulin, ng/ml |
|---|---|---|---|---|---|
| Females | |||||
| BB (n = 43) | 5.8 ± 2.0 × 105 | 342 ± 45 | 48 ± 16 | 292 ± 42 | 1.12 ± 0.79 (n = 16) |
| MB (n = 39) | 4.2 ± 2.1 × 105* | 341 ± 51 | 53 ± 14 | 286 ± 54 | 1.37 ± 1.12 (n = 7) |
| Males | |||||
| BB (n = 47) | 4.4 ± 1.8 × 105 | 379 ± 50 | 66 ± 17 | 312 ± 47 | 3.42 ± 2.21 (n = 17) |
| MB (n = 45) | 2.9 ± 1.8 × 105** | 364 ± 60 | 72 ± 12 | 287 ± 61 | 3.18 ± 1.77 (n = 20) |
BB, homozygous for C57BL/6J alleles; MB, heterozygous for C57BL/6J and MOLF alleles.
*
, P < 0.0009 vs. BB;
**
, P < 0.0002 vs. BB. Values are mean ± SD.