Figure 1. Survival of mice following infection with DENV.

Survival was monitored for 30 days in 5–6 week old mice infected i.v. with DENV2 strain D2S10 or D2S20. (a) AG129 mice were inoculated with 10⁹ or 10¹⁰ GE (4–5 mice per group). Differences in survival between all groups were statistically significant (p<0.005) except between groups infected with D2S10 (p = 0.0139) using the log-rank test (4–5 mice per group). (b) IFNAR^−/− mice were inoculated with 10¹⁰ or 10¹¹ GE (6 mice per group). Statistically significant differences were observed between mice infected with 10¹¹ GE D2S10 and 10¹¹ GE D2S20 (p = 0.0040).