Table 2. Patients’demographic and clinical characteristics of septic patients.
| Survival (n = 145) | Non-survival (n = 83) | p-value | |
| Gender male – n (%) | 94 (64.8) | 56 (67.5) | 0.77 |
| Age - median years (p 25–75) | 55 (44–66) | 64 (55–74) | 0.001 |
| Diabetes mellitus – n (%) | 41 (28.3) | 31 (37.3) | 0.18 |
| Chronic renal failure – n (%) | 8 (5.5) | 8 (9.6) | 0.28 |
| COPD – n (%) | 16 (11.0) | 13 (15.7) | 0.31 |
| Ischemic heart disease - n (%) | 13 (9.0) | 6 (7.2) | 0.80 |
| Site of infection | 0.68 | ||
| · Respiratory - n (%) | 81 (55.9) | 48 (57.8) | |
| · Abdominal - n (%) | 39 (26.9) | 22 (26.5) | |
| · Neurological | 3 (2.1) | 0 | |
| · Urinary - n (%) | 8 (5.5) | 5 (6.0) | |
| · Skin - n (%) | 8 (5.5) | 3 (3.6) | |
| · Endocarditis - n (%) | 6 (4.1) | 4 (4.8) | |
| · Osteomyelitis - n (%) | 0 | 1 (1.2) | |
| Microorganism responsibles | |||
| · Unkwon - n (%) | 77 (53.1) | 47 (56.6) | 0.68 |
| · Gram-positive- n (%) | 32 (22.1) | 19 (22.9) | 0.87 |
| · Gram-negative- n (%) | 35 (24.1) | 17 (20.5) | 0.62 |
| · Fungii- n (%) | 4 (2.8) | 4 (4.8) | 0.47 |
| · Anaerobe- n (%) | 1(0.7) | 1 (1.2) | 0.99 |
| Bloodstream infection | 22 (15.2) | 11(13.3) | 0.84 |
| Empiric antimicrobial treatment adequate | 0.85 | ||
| · Unkown due to negative cultures- n (%) | 77 (53.1) | 47 (56.6) | |
| · Adequate - n (%) | 58 (40.0) | 31 (37.3) | |
| · Unkown due to antigenuria diagnosis-n(%) | 4 (2.8) | 3 (3.6) | |
| · Inadequate- n (%) | 6 (4.1) | 2 (2.4) | |
| Betalactamic more aminoglycoside - n (%) (%)aminoglycoside- n (%) | 28 (19.6) | 20 (24.1) | 0.50 |
| Betalactamic more quinolone - n (%) | 79 (55.2) | 44 (53.0) | 0.78 |
| Pa02/FI02 ratio - median (p 25–75) | 177 (118–261) | 180 (104–247) | 0.41 |
| Creatinine (mg/dl) - median (p 25–75) | 1.20 (0.80–1.90) | 1.50 (0.90–2.80) | 0.03 |
| Bilirubin (mg/dl) - median (p 25–75) | 0.90 (0.46–1.55) | 1.10 (0.50–2.50) | 0.49 |
| Leukocytes -median*103/mm3 (p 25–75) | 14.9 (10.0–20.4) | 15.1 (8.7–20.4) | 0.83 |
| Lactic acid - median mmol/L (p 25–75) | 2.00 (1.10–3.60) | 3.50 (1.40–6.00) | <0.001 |
| Platelets - median*103/mm3 (p 25–75) | 192 (131–273) | 129 (77–219) | <0.001 |
| INR - median (p 25–75) | 1.27 (1.10–1.54) | 1.41 (1.14–1.88) | 0.01 |
| aPTT - median seconds (p 25–75) | 32 (28–41) | 36 (29–46) | 0.006 |
| SOFA score - median (p 25–75) | 9 (7–11) | 11 (9–15) | <0.001 |
| APACHE-II score - median (p 25–75) | 19 (14–22) | 23 (18–28) | <0.001 |
| MDA - median nmol/mL(p 25–75) | 2.89 (2.04–4.05) | 3.93 (2.45–7.37) | 0.002 |
| TNF-alpha median pg/ml (percentile 25–75) | 30 (20–50) | 39 (18–75) | 0.41 |
| IL-10 - median pg/ml (percentile 25–75) | 11 (5–37) | 40 (8–138) | 0.004 |
COPD = chronic obstructive pulmonary disease; PaO2/FIO2 = pressure of arterial oxygen/fraction inspired oxygen; aPTT = Activated partial thromboplastin time; INR = International normalized ratio; APACHE-II = Acute Physiology and Chronic Health Evaluation-II; SOFA = Sepsis-related Organ Failure Assessment; TNF = Tumor necrosis factor; IL = Interleukin; data are presented as number (percentage) or median (interquartile range).