Fig. 7.

Effects of PSD95 on recombinant NR kinetics. A and B: summary of changes in closed component durations of single channel records obtained from cells expressing N1/2B (A) or N1/2A (B) receptors alone [PSD95(−), with mean durations below] and in conjunction with PSD95 [PSDD95(+)] as well as the reaction mechanism deduced from single channel records. All rates are in s⁻¹; mean rate constants for NRs alone are shown in Fig. 3. *Significant differences in means relative to cells expressing NRs alone (P < 0.05 by Student's t-test). Macroscopic traces were simulated with the models shown in Fig. 3 (black) and overlaid with traces simulated with the models given at the left (gray) for each receptor subtype.