Table 4. FISH results in the heterogeneous cases (hetMNA and het11q-del).
| ID | MYCN | 11q | 1p | 17q |
| 11 | 5∶35 15%; 5∶5 80%; 2∶2 5% | 2∶1 35%; 3∶2 35%; 3∶3 15%; 2∶2 15% | (4∶1, 5∶1, 6∶1) 60%; (4∶2,5∶2,6∶2,4∶3,5∶3,6∶3) 20%; 2∶2 20% | 2∶4 30%; 3∶5 30%; 3∶4 30%; 2∶2 10% |
| 12 | 2∶50–100 dmins 10%, 4∶50–100 dmins 20%; 4∶4 40%; 2∶2 30% | 2∶1 25%; 3∶1 25%; 3∶3 10%; 2∶2 40% | 2∶1 10%; 4∶2 5%; 4∶4 35%; 2∶2 50% | 2∶3 50%; 2∶4 15%; 2∶5 15%; 2∶2 20% |
| 13 | 2:>100 dmins 10%; 2∶3 40%; 4∶4 10%; 2∶2 40% | 3∶1 70%; 3∶3 10%; 4∶4 5%; 2∶2 15% | ND | ND |
| 14 | 2∶20 dmins <5%; 2∶2 95% | 2∶1 60%; 2∶2 40% | 3∶3 10%; 4∶4 15%; 2∶2 75% | ND |
| 15 | 2:>100 dmins 5%; 2∶2 95% | 2∶1 25%; 3∶1 25%; 3∶3 10%; 2∶2 40%, | 2∶1 20%; 2∶2 80% | 2∶3 50%; 2∶4 15%; 2∶5 15%; 2∶2 20% |
| 16 | (2∶10,2∶12) 35%; (4∶6,2∶3,2∶6) 30%; 2∶2 35% | 2∶1 15%; 3∶1 30%; 3∶3 15%; 2∶2 30% | 2∶1 40%; 2∶2 60% | ND |
| 17 | 4:>50 dmins 10%; 2:>50 dmins 5%; 4∶4 60%; 8∶8 5%; 2∶2 10% | 3∶1 25%; 3∶3 15%; 2∶2 60% | 4∶1 10%; 2∶1 10%; 4∶2 70%; 2∶2 10% | ND |
| 18 | 3:>100 dmins 20%, 2:>100 dmins 20%, 4:>100 dmins 50%; 2∶2 10% | 2∶1 20%; 2∶2 80% | 2∶3 10%; 4∶4 10%; 2∶2 80% | 2∶3 50%; 2∶2 50% |
Disomic cells (ratio 2∶2) and numeric alterations (ratios 3∶3; 4∶4…), balanced ratio between the signal numbers of chromosomal region of interest and the reference signals on the opposite arm of the chromosome; Cells with gain (ie ratios 2∶4; 3∶4…), signal numbers of the chromosomal region of interest exceed up to 4-fold the number of reference signals; Cells with imbalance (ie ratios 3∶2; 4∶3…), imbalance ratio between the signal numbers of chromosomal region of interest and the reference signals with more than 1 signals of chromosomal region of interest; Cells with deletion (ie. ratios 2∶1; 3∶1 4∶1…), unbalanced ratio between the signal numbers of the chromosomal region of interest and the reference signals with only 1 signal of the chromosomal region of interest; hetMNA, occurrence of clusters or as single cells with amplification (at least five cells per slide) surrounded by non-amplified tumor cells.
ND, not done.
The cases have been listed according to chromosome 2 aberrations using pangenomic techniques.