Table 2. Factor associated with anti-hypertensive switching within 6 months after the first prescription.
| Crude OR | Adjusted OR | Adjusted OR | Adjusted OR with propensity score | |
| (with SBP and DBP) | (with SBP and DBP) | |||
| Age | ||||
| ≤49 | 1.00 | 1.00 | 1.00 | 1.00 |
| 50–59 | 1.51 (1.38, 1.64)* | 1.36 (1.25, 1.49)* | 1.03 (0.93, 1.15) | 0.91 (0.75, 1.09) |
| 60–69 | 1.62 (1.49, 1.76)* | 1.39 (1.27, 1.51)* | 0.97 (0.87, 1.09) | 0.80 (0.60, 1.06) |
| ≥70 | 1.71 (1.59, 1.85)* | 1.42 (1.31, 1.54)* | 0.99 (0.88, 1.11) | 0.79 (0.53, 1.16) |
| Gender | ||||
| Male | 1.00 | 1.00 | 1.00 | 1.00 |
| Female | 0.76 (0.72, 0.80)* | 0.71 (0.67, 0.75)* | 0.65 (0.61, 0.70)* | 0.37 (0.27, 0.51)* |
| Payment status | ||||
| Public assistance | 1.07 (0.99, 1.14) | 0.92 (0.85, 0.99)* | 0.94 (0.87, 1.03) | 0.93 (0.85, 1.02) |
| Others | 1.00 | 1.00 | 1.00 | 1.00 |
| Service Type | ||||
| In-/Day- Patient | 1.25 (1.07, 1.47)* | 1.17 (0.99, 1.38) | 1.02 (0.85, 1.22) | 1.14 (0.77, 1.69) |
| Specialist Out-Patient | 0.67 (0.57, 0.79)* | 0.74 (0.63, 0.87)* | 0.71 (0.59, 0.85)* | 0.94 (0.70, 1.27) |
| Accident & Emergency | 1.13 (0.94, 1.36) | 1.20 (0.99, 1.44) | 1.16 (0.95, 1.42) | 0.34 (0.12, 0.99)* |
| General Out-Patient | 1.15 (0.98, 1.35) | 1.11 (0.94, 1.30) | 1.04 (0.87, 1.23) | 0.65 (0.43, 0.99)* |
| Others | 1.00 | 1.00 | 1.00 | |
| District | ||||
| Hong Kong | 1.00 | 1.00 | 1.00 | 1.00 |
| Kowloon | 1.40 (1.29, 1.52)* | 1.48 (1.36, 1.61)* | 1.70 (1.54, 1.88)* | 1.83 (1.49, 2.26)* |
| New Territories | 1.33 (1.23, 1.43)* | 1.37 (1.27, 1.48)* | 1.33 (1.21, 1.46)* | 1.06 (0.81, 1.38) |
| Drug Class | ||||
| ACEI | 1.00 | 1.00 | 1.00 | 1.00 |
| alpha-Blockers | 0.45 (0.38, 0.52)* | 0.36 (0.30, 0.42)* | 0.43 (0.35, 0.51)* | 0.43 (0.36, 0.52)* |
| beta-Blockers | 0.69 (0.64, 0.75)* | 0.88 (0.80, 0.95)* | 0.98 (0.88, 1.09) | 0.98 (0.88, 1.09) |
| CCB | 0.97 (0.90, 1.06) | 0.97 (0.89, 1.05) | 1.01 (0.90, 1.12) | 1.01 (0.90, 1.12) |
| Thiazide | 1.25 (1.13, 1.38)* | 1.39 (1.25, 1.55)* | 1.49 (1.31, 1.69)* | 1.48 (1.31, 1.69)* |
| Co-morbidity | ||||
| (diagnosed within 180 days) | ||||
| No | 1.00 | 1.00 | 1.00 | 1.00 |
| Yes | 1.64 (1.55, 1.73)* | 1.50 (1.41, 1.59)* | 1.48 (1.38, 1.59)* | 1.48 (1.38, 1.59)* |
| Systolic blood pressure (mmHg) | 1.02 (1.02, 1.02)* | 1.02 (1.02, 1.02)* | 1.02 (1.02, 1.02)* | |
| Diastolic blood pressure (mmHg) | 1.00 (1.00, 1.01)* | 0.99 (0.99, 1.00) | 0.99 (0.99, 1.00)* | |
*
denotes p<0.05. ACEI: Angiotensin converting enzyme inhibitors; CCB: Calcium channel blockers.