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. 2012 May 30;108(5):1318–1334. doi: 10.1152/jn.00907.2011

Fig. 5.

Fig. 5.

Activation and steady-state inactivation properties of Na+ currents in GG neurons. A: selective activation of fast-inactivating TTX-resistant (TTX-R) Na+ currents (top) was achieved with depolarizing pulses from a holding potential of −120 mV (bottom) in 0.1 μM TTX. B: steady-state inactivation of TTX-R currents (top) was characterized by depolarizing pulses to a test potential of −10 mV from various prepulse potentials (bottom) in 0.1 μM TTX. C: the current-voltage (I-V) relationship for TTX-R currents demonstrates their reversal potential near +50 mV. D: Hodgkin-Huxley activation (τm) and inactivation (τh) time constants for TTX-R currents were fast and voltage dependent. E: activation and steady-state inactivation curves of TTX-R and TTX-S currents. Fits are reported in text. Activation properties of TTX-S currents were characterized by test depolarizations from holding potentials more positive than −70 mV; steady-state inactivation properties were calculated by subtraction of TTX-R currents from total Na+ currents. F: the total activation curve of Na+ currents, derived from depolarizing pulses from a holding potential of −120 mV in saline, shows contributions from activation curves of isolated TTX-R (−120 mV, TTX) and TTX-S currents (−70 mV). Error bars in C–F represent SE. Vm, membrane potential.