Table 3.
New infectious virus particle production at 16h p.i. after 48hr pre-treatment with JAK Inh. I
| PDA Cells | Treatmenta | Yieldb | Ratioc |
|---|---|---|---|
| AsPC-1 | VSV | 8.4×107 | 1 |
| VSV + 0.5 μM JAK Inh. I | 4.2×108 | 5 | |
| VSV + 2.5 μM JAK Inh. I | 2.6×108 | 3 | |
| CFPAC | VSV | 1.3×106 | 1 |
| VSV+ 0.5 μM JAK Inh. I | 2.6×107 | 20 | |
| VSV + 2.5 μM JAK Inh. I | 2.1×107 | 16 | |
| HPAC | VSV | 2.6×106 | 1 |
| VSV + 0.5 μM JAK Inh. I | 3.1×107 | 12 | |
| VSV + 2.5 μM JAK Inh. I | 7.9×106 | 3 | |
| HPAF-II | VSV | 2.0×104 | 1 |
| VSV + 0.5 μM JAK Inh. I | 1.3×106 | 64 | |
| VSV + 2.5 μM JAK Inh. I | 5.2×106 | 256 | |
| Hs766T | VSV | 4.1×104 | 1 |
| VSV + 0.5 μM JAK Inh. I | 2.1×107 | 512 | |
| VSV + 2.5 μM JAK Inh. I | 1.0×107 | 256 | |
| MIA PaCa-2 | VSV | 4.2×108 | 1 |
| VSV + 0.5 μM JAK Inh. I | 5.0×108 | 1.2 | |
| VSV + 2.5 μM JAK Inh. I | 2.1×108 | 0.5 | |
| Suit2 | VSV | 2.1×108 | 1 |
| VSV + 0.5 μM JAK Inh. I | 1.3×108 | 0.6 | |
| VSV + 2.5 μM JAK Inh. I | 8.4×107 | 0.4 | |
| HPDE | VSV | 6.1×104 | 1 |
| VSV + 0.5 μM JAK Inh. I | 1.3×108 | 2048 | |
| VSV + 2.5 μM JAK Inh. I | 1.3×108 | 2048 |
“VSV” indicates VSV-Δ M51-GFP
Virus was collected from the indicated cell line and titer was determined on BHK-21 cells
Ratio of virus yield on JAK Inh. I treated cells to mock treated cells