Table 1.

Regional functional connections that showed significant group differences over 12-month exercise intervention.

ROI abbreviations	ROI-ROI anatomical regions		Hypothesized network	Intervention effect
BMTG – BPHG	Bilateral middle temporal gyrus L: −52,−18,−18 R: 58, −10,−18	Bilateral parahippocampal gyrus L: −24,−26,−20 R: 24,−26,−20	DMN	W > S
BPHG - LOC	Bilateral parahippocampal gyrus L: −24,−26,−20 R: 24,−26,−20	Left lateral occipital/parietal cortex −44,−72,34	DMN	W > S
LMFG - BMTG	Left middle frontal gyrus −30,20,50	Bilateral middle temporal gyrus L: −52,−18,−18 R: 58, −10,−18	DMN	W > S
RALPFC - PFC	Right anterior lateral prefrontal cortex 32,40,28	Bilateral prefrontal cortex L: −36,34,28 R: 32, 42, 36	Fronto-executive/CO	W > S
RALPFC - LHC	Right anterior lateral prefrontal cortex 32,40,28	Left hippocampus −24,−22,−18	Fronto-executive/CO-AND-DMN	-W > -S
RFOI - RLOC	Right frontal operculum/insula 28, 26, 8	Right lateral occipital/parietal cortex 26,−64,54	Fronto-executive/CO-AND-Fronto-parietal	S > W

All coordinates are in MNI space, L and R refer to Left and Right hemisphere, respectively. Networks, DMN=Default Mode Network, CO=cingulo-opercular network, which is another name for the fronto-executive network. Group effects, W=walking group, S=flex, tone, and balance control group.