Table 3.
Demographic and ocular features of Glaucoma Genes and Environment (GLAUGEN) and National Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) cases with binary glaucoma feature variables.
| GLAUGEN | NEIGHBOR | |||
|---|---|---|---|---|
| Variable | % > cutoff | N | % > cutoff | N |
| Age at diagnosis ≥ 65 years | 49.3 | 976 | 56.5 | 1971 |
| Gender (% female) | 58.4 | 976 | 52.1 | 1971 |
| Intraocular pressure ≥ 22 mm Hg at diagnosis | 67.0 | 976 | 79.4 | 1219 |
| Cup-disc ratio ≥ 0.6 at diagnosis | 69.9 | 458 | n/a | n/a |
| Cup-disc ratio ≥ 0.6 at DNA collection | 96.3 | 485 | 95.8 | 1611 |
| Laser trabeculoplasty | 28.2 | 976 | 36.8 | 38 |
| Incisional glaucoma surgery | 15.1 | 976 | 55.0 | 40 |
| Pattern standard deviation ≥ 6 decibels | 39.8 | 802 | 45.4 | 1119 |
| Mean defect ≤ −13 decibels | 14.6 | 849 | 26.6 | 1357 |
| Peripheral visual field loss only* | 52.1 | 963 | 31.5 | 1423 |
| Paracentral visual field loss only * | 17.9 | 963 | 3.0 | 1423 |
| Both peripheral and paracentral visual field loss* | 30.0 | 963 | 65.1 | 1423 |
| Superior visual field loss only* | 38.8 | 963 | 27.6 | 1423 |
| Inferior visual field loss only* | 30.3 | 963 | 21.2 | 1423 |
| Both superior and inferior visual field loss* | 28.8 | 963 | 50.7 | 1423 |
These visual field loss attributes are applied on a per patient basis. For instance, peripheral visual field loss only means that one or both eyes of a patient have peripheral visual field loss and neither has paracentral field loss.
Abbreviations used: DNA= Deoxyribonucleic acid; n/a=not available
NB: Certain phenotype features were absent on some subsets of GLAUGEN and NEIGHBOR. We included data on CDR >0.6 at diagnosis from the Nurses Health Study (NHS) and Health Professionals Follow-up Study (HPFS) subsets of GLAUGEN. We included data on CDR>0.6 at DNA collection from the Mass Eye and Ear Infirmary (MEEI) subset of GLAUGEN and all NEIGHBOR sites. For laser trabeculoplasty and incisional glaucoma surgery we included data from GLAUGEN as well as the Collaborative Initial Glaucoma Treatment Study and Advanced Glaucoma Intervention Study sub sites of NEIGHBOR. Missing data for the visual field parameters (mean defects and pattern standard deviation) solely reflects the fact that some participants had visual field tests other than Humphrey tests. Missing data for parameters related to the pattern of visual loss (e.g. peripheral visual field loss only) occurred for several reasons including visual field loss was confounded from deficits not attributable to glaucoma like age-related macula or tests assessed segments outside the range of the central 24 or 30 degrees.