Table 1.
Mutant | Genotype | Blood Pressure Phenotype | Ref |
---|---|---|---|
nNOS−/− | nNOSβ splice variant present | Normotensive | [124] |
nNOS−/− | Null mutation | Normotensive | [125] |
eNOS−/− | Null mutation | Hypertensive | [38,39,126,127]’’’ |
iNOS−/− | Null mutation | Normotensive | [128–130]’’ |
n/iNOS−/− | nNOSβ splice variant present | Normotensive | [131,132]’’ |
n/eNOS−/− | nNOSβ splice variant present | Hypertensive | ’[131–133] |
e/iNOS−/− | nNOSβ splice variant present | Hypertensive | [131,132]’ |
e/i/nNOS−/− | nNOSβ splice variant present | Hypertensive | [132] |
nNOS transgenic | Conditional myocardial overexpression | Normotensive | [134,135] |
Brain overexpression | Normotensive | [136] | |
eNOS transgenic | Myocardial overexpression | Normotensive | [137,138] |
Endothelial overexpression | Hypotensive | [139,140]’ | |
iNOS transgenic | Conditional myocardial overexpression | Normotensive | [141] |
Myocardial overexpression | Normotensive | [142] | |
Pancreatic β cell overexpression | Normotensive | [143] | |
sGCα1−/− | Null mutation | Mild Hypertensive | [25] |
sGCα1−/− | Truncated inactive protein | Normotensive on C57Bl/6 Hypertensive on 129S6 |
[22] |
sGCα2−/− | Null mutation | Normotensive | [25] |
sGCβ1−/− | Null mutation | Hypertensive | [12] |
sGCβ1H105F | NO-insensitive mutant protein | Hypertensive | [54] |
PKG1−/− | Null mutation | Hypertensive at 6W Normotensive at >= 8W |
[57] |
PKG1 SMα rescue | PKG1α only in SMC of PKG1−/− | Normotensive | [55] |
PKG1 SMβ rescue | PKG1β only in SMC of PKG1−/− | Normotensive | [55] |
PKG-LZM | Mutant protein | Hypertensive at >=12W | [11] |
PKG1αC42S | H2o2-insensitive mutant protein | Hypertensive | [61] |
PKG2−/− | Null mutation | Normotensive | [144] |
PDE5 transgenic | Myocardial overexpression | Normotensive | [145] |