Table 1.

Overview of the different mutant mouse strains in NO-cGMP signaling that have been generated, including their effect on blood pressure regulation.

Mutant	Genotype	Blood Pressure Phenotype	Ref
nNOS−/−	nNOSβ splice variant present	Normotensive	[124]
nNOS−/−	Null mutation	Normotensive	[125]
eNOS−/−	Null mutation	Hypertensive	[38,39,126,127]’’’
iNOS−/−	Null mutation	Normotensive	[128–130]’’
n/iNOS−/−	nNOSβ splice variant present	Normotensive	[131,132]’’
n/eNOS−/−	nNOSβ splice variant present	Hypertensive	’[131–133]
e/iNOS−/−	nNOSβ splice variant present	Hypertensive	[131,132]’
e/i/nNOS−/−	nNOSβ splice variant present	Hypertensive	[132]
nNOS transgenic	Conditional myocardial overexpression	Normotensive	[134,135]
	Brain overexpression	Normotensive	[136]
eNOS transgenic	Myocardial overexpression	Normotensive	[137,138]
	Endothelial overexpression	Hypotensive	[139,140]’
iNOS transgenic	Conditional myocardial overexpression	Normotensive	[141]
	Myocardial overexpression	Normotensive	[142]
	Pancreatic β cell overexpression	Normotensive	[143]
sGCα1−/−	Null mutation	Mild Hypertensive	[25]
sGCα1−/−	Truncated inactive protein	Normotensive on C57Bl/6 Hypertensive on 129S6	[22]
sGCα2−/−	Null mutation	Normotensive	[25]
sGCβ1−/−	Null mutation	Hypertensive	[12]
sGCβ1H105F	NO-insensitive mutant protein	Hypertensive	[54]
PKG1−/−	Null mutation	Hypertensive at 6W Normotensive at >= 8W	[57]
PKG1 SMα rescue	PKG1α only in SMC of PKG1−/−	Normotensive	[55]
PKG1 SMβ rescue	PKG1β only in SMC of PKG1−/−	Normotensive	[55]
PKG-LZM	Mutant protein	Hypertensive at >=12W	[11]
PKG1αC42S	H2o2-insensitive mutant protein	Hypertensive	[61]
PKG2−/−	Null mutation	Normotensive	[144]
PDE5 transgenic	Myocardial overexpression	Normotensive	[145]