Table 1.
Properties of CINs from different postnatal age groups
| P0–3 | P8–10 | P14–16 | |
|---|---|---|---|
| Spontaneous firing at zero current, Hz | 3.0 ± 0.6 (11/56) | 4.5 ± 4.7 (14/21) | 6.7 ± 7.0 (17/27) |
| Rest potential of silent cells, mV | −60.0 ± 4.3 (45/56) | −56.1 ± 6.0 (7/21) | −56.9 ± 6.3 (10/27) |
| Input resistance, MΩ | 618.4 ± 250.9 (31) | 480 ± 282 (25) | 630 ± 333 (19) |
| Mean capacitance, pF | 67.0 ± 13.2 (56) | 51.9 ± 34.8* (22) | 51.7 ± 26.5* (19) |
| AP halfwidth, ms | 3.0 ± 0.5 (57) | 1.6 ± 0.2* (25) | 1.2 ± 0.4*† (19) |
| AP threshold, mV | −39.7 ± 6.6 (57) | −35.6 ± 5.6* (25) | −37.7 ± 5.1 (19) |
| AP amplitude, mV | 62.3 ± 7.8 (57) | 80.4 ± 9.8* (25) | 65.0 ± 10.0† (19) |
| Minimum AHP voltage, mV | −56.6 ± 5.8 (57) | −58.5 ± 6.4 (25) | −56.8 ± 5.7 (19) |
| AHP time (slow), ms | 25.3 ± 7.5 (31) | 34.7 ± 8.4* (25) | 35.3 ± 12.0* (16) |
| AHP time (fast), ms | 3.2 ± 1.4 (8) |
Values are means ± SD in different postnatal (P) age groups; numbers in parentheses indicate no. of commissural interneuons (CINs). AP, action potential; AHP, afterhyperpolarization.
*
P < 0.05, significantly different from P0–P3.
†
P < 0.05, significantly different from P8–P10.