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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Sep 10;1829(1):127–133. doi: 10.1016/j.bbagrm.2012.09.001

Figure 2. Ccr4-Not promotes transcription through nucleosomes by regulating histone modifications and rescuing arrested RNAPII.

Figure 2

The elongation complex encounters a nucleosome with low H3 K4me3 levels caused by the presence of Jhd2. Jhd2 is polyubiquitylated by Not4 and ultimately destroyed by the proteasome. This leads to an increase in H3K4me3 and recruitment of nucleosome remodeling activities, removing the nucleosomal barrier. The collision of RNAPII with the nucleosome caused backtracking, which is then relieved by Ccr4-Not.