Fig. 1.

Medial view localizing abnormally low CMRgl (blue) in the PCC in young adult carriers of the APOE ε4 allele, and a summary of brain imaging results thus far reported in similarly-aged young adults and children (citations in text). Widespread changes in neuroenergetics and brain structure point to a neurodevelopmental role for APOE and early interference by the APOE ε4 allele, but this is yet to be confirmed. CMRgl=cerebral metabolic rate for glucose; PCC=posterior cingulate cortex; OXPHOS=oxidative phosphorylation; CO=cytochrome oxidase, Complex IV of the ETC; DMN=default mode network; DTI=diffusion tensor imaging