Table 1.
Clinical and pathological characteristics of lung adenocarcinomas with and without tumor islands
| Variable | Island (−) n=203 |
Islands (+) n=58 |
P value |
|---|---|---|---|
| Age (y); median (range) | 69 (37–92) | 68.5 (47–83) | 0.253 |
| Gender (F; %) | 126 (62.1) | 30 (51.7) | 0.173 |
| Smoking History (Pack-year); median (range) | 30 (0–730) | 40 (0–140) | 0.060 |
| Tumor size (cm); median (range) | 2.3 (0.6–15.0) | 2.05 (0.4–6.5) | 0.283 |
| Specimen type (wedge resection; %) | 66 (32.5) | 16 (27.6) | 0.524 |
| pT (%) | 0.949 | ||
| 1a | 82 (40.4) | 22 (37.9) | |
| 1b | 44 (21.7) | 15 (25.9) | |
| 2a | 57 (28.1) | 16 (27.6) | |
| 2b | 7 (3.4) | 1 (1.7) | |
| 3 | 13 (6.4) | 4 (6.9) | |
| pN (%) | 0.609 | ||
| N0 | 173 (85.2) | 49 (84.5) | |
| N1 | 17 (8.4) | 6 (10.3) | |
| Nx | 13 (6.4) | 3 (5.2) | |
| AJCC Stage | 0.960 | ||
| IA | 116 (57.1) | 35 (60.4) | |
| IB | 53 (26.1) | 13 (22.4) | |
| IIA | 18 (8.9) | 5 (8.6) | |
| IIB | 16 (7.9) | 5 (8.6) | |
| Predominant Histological Pattern (%) | 0.003 | ||
| Minimally invasive adenocarcinoma | 29 (14.3) | 2 (3.5) | |
| Lepidic | 34 (16.8) | 4 (6.9) | |
| Acinar | 90 (44.3) | 25 (43.1) | |
| Papillary | 21 (10.3) | 7 (12.1) | |
| Micropapillary | 8 (3.9) | 6 (10.3) | |
| Solid | 16 (7.9) | 13 (22.4) | |
| Mucinous adenocarcinoma | 5 (2.5) | 1 (1.7) | |
| Nuclear Grade (%) | 0.011 | ||
| 1 | 15 (7.4) | 0 (0) | |
| 2 | 104 (51.2) | 24 (41.4) | |
| 3 | 84 (41.4) | 34 (58.6) | |
| Lymphatic invasion (%) | 45 (22.17) | 19 (32.76) | 0.119 |
| Vascular invasion (%) | 23 (11.3) | 8 (13.8) | 0.646 |
| Pleural invasion (%) | 34 (16.8) | 13 (22.4) | 0.336 |