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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Apoptosis. 2013 Jan;18(1):1–8. doi: 10.1007/s10495-012-0763-9

Fig. 4. Nifedipine prevents etoposide induced caspase-3 activation and FTase/GGTase-α degradation in rat islets.

Fig. 4

Fig. 4

Rat islets were treated with either diluents (DMSO and/or ethanol) or etoposide (ET) (60 μM) in the presence or absence of Nifedipine (Nif; 10 μM; 12 h). Caspase-3 activation and FTase/GGTase-α degradation were determined by Western blot analysis. Protein loading was determined by actin content in individual lanes. Data are representative of four independent experiments. A representative blot indicating the caspase-3 activation (a) and FTase/GGTase-α degradation (c) is shown here. Quantitation of the active caspase-3 (b) and FTase/GGTase-α degradation (d) was carried out by densitometry. Results are shown as means ± SEM. *p < 0.05, **p < 0.01