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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Dec 17;115(2):201–211. doi: 10.1016/j.oooo.2012.09.008

Fig. 7.

Fig. 7

Radiation-related hypoxia and oxidative stress. Relative to non-irradiated bone (A, C), hypoxia was upregulated in irradiated mandible (B) and tibia (D) based on stronger Immunoreactivity to HIF1α in the bone trabeculae (black arrowheads) and marrow elements (black stars). Unlike the tibia, irradiated mandibular vasculature was highly immunoreactive (black arrowheads) to anti-MDA relative to non-irradiated mandible (E, F, G, H).