. Author manuscript; available in PMC: 2014 Feb 1.

Published in final edited form as: Brain Behav Immun. 2012 Oct 16;28:25–43. doi: 10.1016/j.bbi.2012.09.013

Table 3.

Measures of several variables significantly modulated by daily exercise in aging rats correlate. Spearman rank correlation coefficients (r_s) were calculated test the strength of the relationships between concentrations of serum (S), hippocampal (H) and cortical (C) cytokines, and measures of spatial and hippoocampal neurogenesis that were significantly modulated by conditioned running.

	SERUM			HIPPOCAMPUS			CORTEX	NEUROGENESIS & BEHAVIOR

	MCP-1	leptin	GRO-KC	IL-1β	IL-18	GRO-KC	VEGF	New Neuron #	Immed. DI	24 hr DI	24 hr IA
MCP-1 (S)		0.65⁺	0.96^***	0.54	−0.36	−0.14	0.13	−0.53	−0.81^**	−0.39	−0.30
leptin (S)	0.65⁺		0.56⁺	0.76^*	−0.61⁺	−0.58⁺	0.52	−0.77^**	−0.73^*	−0.78^**	−0.46
GRO-KC (S)	0.96^***	0.56⁺		0.42	−0.29	−0.20	0.07	−0.41	−0.75^**	−0.48	−0.18
IL-1β (H)	0.54	0.76^*	0.42		−0.60^*	−0.25	0.57⁺	−0.58⁺	−0.58⁺	−0.68^*	−0.63^*
IL-18 (H)	−0.36	−0.61⁺	−0.29	−0.60^*		0.85^***	−0.51	0.94^***	0.51	0.54	0.16
GRO-KC (H)	−0.14	−0.58⁺	−0.20	−0.25	0.85^***		−0.37	0.79^**	0.38	0.41	−0.11
VEGF (C)	0.13	0.52	0.07	0.57⁺	−0.51	−0.37		−0.43	−0.64^*	−0.51	−0.60^*
New Neuron #	−0.53	−0.77^**	−0.41	−0.58⁺	0.94^***	0.79^**	−0.43		0.59⁺	0.55⁺	0.18
Immed. DI	−0.81^**	−0.73^*	−0.75^**	−0.58⁺	0.51	0.38	−0.64^*	0.59⁺		0.47	0.45
24 hr DI	−0.39	−0.78^**	−0.48	−0.68^*	0.54	0.41	−0.51	0.55⁺	0.47		0.62^*
24 hr IA	−0.30	−0.46	−0.18	−0.63^*	0.16	−0.11	−0.60⁺	0.18	0.45	0.62^*

^***

p < 0.001,

^**

p<0.01,

p < 0.05 and

⁺

0.05 < p < 0.10.