Fig. 4.
Dose response curve of HRV in differentiated HSEC. Differentiated HSEC cultures (n=3) were infected with HRV-C15 or HRV-A16 virions serially diluted (5×108–5×103 RNA copies per well), and cell-associated viral RNA was quantitated immediately post-inoculation (PI) and 24 h later. Panels (A) and (B) illustrate the relationship between input virus, viral binding, and viral yield after 24 h for HRV-C15 and HRV-A16 respectively. These same data were replotted to illustrate the relationship between inoculum dose and net increase in viral RNA (C), and the relationship between viral binding and viral yield for the two viruses (D). *P<0.05.