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Effect of age of culture on HRV-C15 replication. HSEC cultures (n=3) were allowed to differentiate for one or two months at ALI, and then were infected with HRV-C15 (1×108 RNA copies). Viral replication was measured after 24 h. Differences in the baseline and replication levels of viral RNA between the 1 month and 2 months cultures were determined by the t-test.*P<0.001.
