. 2012 Sep 5;108(10):2751–2766. doi: 10.1152/jn.01120.2011

Table 1.

Antagonist effects on CCh actions in single mAChR knockouts

Condition	n	Effect on Vm, mV	Effect on Rin, %control	Effect on Spike-Evoked dF/F, %control
M₂−/−
Control	4	−2.5 ± 0.8^*	−40.7 ± 14.2^*	−11.2 ± 5.7^*
+ Atropine		−0.8 ± 0.2	+2.3 ± 4.1	−1.0 ± 2.2
Control	4	−2.1 ± 1.4^*	−32.3 ± 10.6^*	−13.9 ± 5.8^*
+ Tertiapin		+2.0 ± 1.5^*	+1.4 ± 12.6	−19.1 ± 16.9^*
Control	4	−2.5 ± 0.5^*	−47.2 ± 10.8^*	−16.3 ± 5.1^*
+ SNX-482		−2.9 ± 0.9^*	−44.6 ± 15.0^*	−5.6 ± 3.4
M₄−/−
Control	7	−5.3 ± 0.9^*	−51.9 ± 8.3^*	−46.2 ± 1.1^*
+ Atropine		+3.5 ± 3.4	+3.2 ± 17.2	−0.8 ± 1.4
Control	3	−5.8 ± 0.7^*	−54.8 ± 21.6^*	−47.6 ± 2.9^*
+ Tertiapin		−0.8 ± 0.2	−25.1 ± 7.3^*	−33.0 ± 2.6^*
Control	4	−2.7 ± 0.8^*	−47.7 ± 15.2^*	−44.9 ± 4.5^*
+ SNX-482		−2.8 ± 0.7^*	−55.2 ± 18.7^*	−10.6 ± 4.4

Values are means ± SE; n, no. of neurons. CCh, carbachol; mAChR, Muscarinic acetylcholine receptors; Vm, membrane potential; Rin, input resistance; dF/F, change in fluorescence.

P < 0.05.