Fig. 3.
mGluR agonists modulate synaptic currents at the immature synapse. Representative traces (left) and time course (right) of AMPAR EPSC responses to pairs of pulses before (thin line) and during (thick line) bath application of the group II mGluR agonist (2R,4R)-4-aminopyrrolidine-2,4,-dicarboxylate (APDC; 30 μM; A), group III agonist l-(+)-2-amino-4- phosphonobutyric acid (l-AP4; 500 μM; B), and group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG; 25 μM; C). Peak amplitude of first (EPSC1; circles) and second AMPAR EPSC (EPSC2; squares) and paired-pulse ratio (PPR; triangles) are plotted. D: summary data of peak EPSCs (top) and PPR (bottom) shown as a percentage of control in the presence of various concentrations of mGluR agonists. #P < 0.05; *P < 0.01. Recordings were performed at 25 ± 1°C.