Fig. 3.

Inflammation-induced increase in efficacy but not potency of GABA current activation. A: representative currents evoked in response to increasing concentrations of GABA applied to a cutaneous neuron from a naive (left) and an inflamed (CFA, right) rat. B: pooled concentration-response curves of peak GABA current in cutaneous neurons from naive and inflamed rats: there was a significant increase in the maximum current in the inflamed group (P < 0.01) compared with naive rats but no change in EC₅₀. C: pooled concentration-response curve of sustained GABA current: there was also a significant increase of sustained current following inflammation (P < 0.01) and no change in EC₅₀.