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. 2012 Aug 22;108(9):2581–2593. doi: 10.1152/jn.00590.2012

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Fig. 4. — Pharmacological analysis of GABA currents in cutaneous neurons from naive and inflamed rats. GABA was applied before (black traces) and after (gray traces) the application of compounds used to facilitate or block specific GABA_A receptor subtypes. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) potentiated GABA currents in cutaneous neurons from both naive and inflamed (CFA) rats (A), where pooled data (B) indicated that the increase in current was significantly larger in neurons from inflamed rats. In contrast, Zn²⁺ attenuated GABA currents in DRG neurons from both naive and inflamed rats (C). Again, the magnitude of the Zn²⁺-sensitive current was significantly larger in neurons from inflamed rats (D). Diazepam (DZP) potentiated GABA-evoked current in cutaneous neurons from both naive and inflamed rats (E); data pooled from neurons responsive to DZP (F) indicated that DZP-induced increase in current was significantly larger in neurons from inflamed rats. *P < 0.05, **P < 0.01.