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. 2013 Jan 1;85(1):29–37. doi: 10.1016/j.bcp.2012.10.004

Fig. 3.

Fig. 3

Intracellular accumulation of Act D following incubation with Act D (0.01 μM) over 12 h in MDCKII-WT, MDCKII-ABCB1, MDCKII-ABCC1, MDCKII-ABCC2 and MDCKII-ABCG2 cell lines (A). Intracellular accumulation with Act D (0.1 μM) over 4 h in the presence of a specific inhibitor (ABCB1 – verapamil, ABCC1/ABCC2 – MK571, ABCG2 – KO143), with MDCKII-WT and MDCKII-ABCB1 (B) and MDCKII-WT, MDCKII-ABCC1 and MDCKII-ABCC2 (C). Cellular efflux after a 4 h incubation with 0.1 μM Act D in all MDCKII cell lines (D). Each point represents mean ± SEM from ≥3 experiments. **p < 0.01, ***p < 0.001, ****p < 0.0001 compared with MDCKII-WT at the same time point.