Table 2.
Act D plasma concentrations and pharmacokinetic parameters in WT, Abcb1a/1b−/− and Abcc2−/− mice following intravenous administration of 0.5 mg/kg Act D.
| Act D concentration (μg/L) |
|||
|---|---|---|---|
| WT | Abcb1a/1b−/− | Abcc2−/− | |
| 0.25 h | 68.6 ± 15.6 | 96.7 ± 12.0* | 48.0 ± 11.1 |
| 0.5 h | 43.3 ± 7.68 | 71.6 ± 12.3* | 37.7 ± 6.07 |
| 2 h | 25.8 ± 4.78 | 35.8 ± 2.01 | 16.3 ± 3.73 |
| 6 h | 6.0 ± 0.65 | 20.1 ± 0.78 | 8.6 ± 0.96 |
| AUC0–6 h (μg/L h) | 151.5 | 242.0 | 114.8 |
| AUC0–∞ (μg/L h) | 168.1 | 322.6 | 145.2 |
| Cmax (μg/L) | 68.6 ± 15.6 | 96.7 ± 12.0 | 48.0 ± 11.1 |
| Tmax (h) | 0.25 | 0.25 | 0.25 |
| t1/2 (h) | 1.92 | 2.78 | 2.46 |
Individual plasma concentration time points are mean ± SD from 3 mice.
*
p < 0.05 compared to the WT.