Table 3.

Act D tissue disposition concentrations and pharmacokinetic parameters in WT, Abcb1a/1b^−/− and Abcc2^−/− mice following intravenous administration of 0.5 mg/kg Act D.

	Liver concentration (μg/L)			Kidney concentration (μg/L)			Brain peak area (pa)
	WT	Abcb1a/1b−/−	Abcc2−/−	WT	Abcb1a/1b−/−	Abcc2−/−	WT	Abcb1a/1b−/−	Abcc2−/−
0.25 h	1810 ± 155	2323 ± 239	1317 ± 302	13,323 ± 3960	13,207 ± 1025	13,107 ± 2318	1071 ± 217	1134 ± 635	972 ± 455
0.5 h	1593 ± 167	1367 ± 133	1540 ± 356	10,713 ± 2498	13,163 ± 2521	10,593 ± 944	775.3 ± 127	1420 ± 521	1039 ± 181
2 h	747 ± 165	737 ± 172	787 ± 99	4693 ± 415	5327 ± 1257	4987 ± 161	501 ± 28.9	912.7 ± 461	424.3 ± 120
6 h	287 ± 40	407 ± 9	303 ± 128	1970 ± 150	2957 ± 872	3410 ± 527	309 ± 156	1383 ± 439	733 ± 470
AUC0–6 h (μg/L h)	4473	4616	4445	29,552	35,381	33,079	2943	6802	3785
AUC0–∞ (μg/L h)	5387	6594	5516	35,754	46,701	48,799	ND	ND	ND
Cmax (μg/L)	1810 ± 155	2323 ± 239	1540 ± 356	13,323 ± 3960	13,207 ± 1025	13,107 ± 2318	1071 ± 217	1420 ± 521	1039 ± 181
Tmax (h)	0.25	0.25	0.5	0.25	0.25	0.25	0.25	0.5	0.5
t1/2 (h)	2.21	3.37	2.44	2.18	2.65	3.2	ND	ND	ND

Individual tissue concentration time points are expressed per gram of tissue and are the mean ± SD from 3 mice. All brain data is expressed as peak area. ND, no data.