Figure 3.

(a) Histology, angiosarcoma, right mastectomy specimen. The primary tumour from the breast is an infiltrative lesion, seen dissecting collagen (thin arrow) and within adipose tissue (thick arrow), and comprising anastomosing vascular channels lined by mildly atypical spindle cells. (b) Immunohistochemistry, angiosarcoma, biopsy from left paraspinal mass. Metastatic tumour, infiltrating paraspinal soft tissue (arrowed), is diffusely positive for CD34, a vascular endothelial marker. (c) Histology, angiosarcoma, small bowel resection. Metastatic tumour is seen infiltrating the muscular is propria (arrowed) of the small bowel. It remains well differentiated, with similar morphology to the primary tumour excised previously from the breast.