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. 2012 Dec 29;2012:185167. doi: 10.1155/2012/185167

Figure 2.

Figure 2

The effects of intrathecal triptolide on SNL-induced mechanical allodynia. SNL injury resulted in prominent mechanical allodynia. However, the intrathecal injection of triptolide did not affect the pain threshold of the Sham-operated group. The intrathecal administration of triptolide (10 or 30 μg/kg, once per day from POD 3 to 6) significantly blocked SNL-induced mechanical allodynia in a dose-dependent manner; in contrast, 3 μg/kg/d of intrathecal triptolide did not alter the SNL-induced mechanical allodynia (a). SNL: spinal nerve ligation; POD: postoperative day. *P < 0.05, compared to the SNL-Veh group. # P <0.05, compared to the SNL-T10 10 μg/kg group. The dose-effect and log- (dose-) effect curves for analgesic effects of triptolide are shown in (b) and (c). Each group consisted of 16 rats.