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. 2012 Dec 29;2012:185167. doi: 10.1155/2012/185167

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Copyright © 2012 Jun Tang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effects of intrathecal triptolide on the expression of phosphorylated forms of NR2B (pNR2B). SNL injury resulted in increased levels of pNR2B in the ipsilateral SDH at POD 6. The intrathecal administration of triptolide (10 μg/kg) also prevented SNL-evoked pNR2B accumulation. SNL, spinal nerve ligation; SDH, spinal dorsal horn; POD, postoperative day. *P < 0.05, SNL-Veh group versus Sham-Veh group; ^# P < 0.05, SNL-T10 group versus SNL-Veh group. The levels of pNR2B are expressed as relative fold changes compared to the Sham-Veh group. Each group consisted of 12 rats.