Table 3.
Mean Numbers of NANOG-, GATA6-, and Double-Positive Inner Cell Mass Cells in Blastocysts with A/B- and C/D-Quality Inner Cell Mass in Different Small-Molecule Groups
| NANOG alone | GATA6 alone | Dp | ICM | |
|---|---|---|---|---|
| A- & B-quality ICM | ||||
| control (n=6) | 7.67±4.59 | 4.50±3.67 | 3.33±3.44 | 15.5±8.96 |
| PD0325901 (n=14) | 15.00±7.30a | 7.00±4.74 | 0.00 | 22.00±10.36 |
| CHIR & PD0325901 (n=11) | 14.27±8.66a | 5.55±5.26 | 0.00 | 19.82±11.75 |
| C- & D-quality ICM | ||||
| control (n=8) | 5.75±3.54 | 9.00±5.18 | 0.63±0.92 | 13.67±7.13 |
| PD0325901 (n=11) | 6.27±2.90 | 5.00±5.83 | 0.00 | 11.27±5.22 |
| CHIR & PD0325901 (n=4) | 5.75±1.71 | 3.25±2.22 | 0.00 | 9.00±3.56 |
Statistic significances compared to control: aP<0.05.
Mean±standard deviation.
Dp, number of double-positive cells for NANOG and GATA6s.