Table 1.
Comparison of E max and pD2 values of KA-acetoxy against tonic contractions induced by phenylephrine in isolated rat mesenteric rings.
| Phenylephrine 10 (μM) | E max | pD2 |
|---|---|---|
| (condition) | (percentage of relaxation) | (value) |
| Endothelium intact | 92.8 ± 3.7 | 6.0 ± 0.3 |
| Endothelium denuded | 95.2 ± 2.8 | 4.6 ± 0.2*** |
| L-NAME (100 μM) | 67.3 ± 4.3*** | 4.1 ± 0.1*** |
| Indomethacin (10 μM) | 61.2 ± 7.4*** | 4.5 ± 0.3* |
| L-NAME + indomethacin | 66.9 ± 3.6*** | 4.7 ± 0.3* |
| Atropine (1 μM) | 73.6 ± 6.6* | 4.4 ± 0.2*** |
| ODQ (10 μM) | 77.7 ± 3.6* | 4.6 ± 0.5* |
| Hydroxycobalamine (10 μM) | 68.1 ± 6.7** | 4.6 ± 0.3* |
| L-arginine (1000 μM) | 91.4 ± 2.9 | 5.4 ± 0.4 |
| L-NAME + L-arginine | 100 ± 0 | 5.3 ± 0.4 |
Values are expressed as means ± SEM of six experiments. These experiments were performed in mesenteric rings with functional endothelium. *P < 0.05, **P < 0.01 and ***P < 0.001 versus endothelium intact. The data were analysed by one-way Anova followed by the Bonferroni post-test.