Figure 1.

Study design diagram. A: The first cohort (n = 8 mice) was imaged 13 days after tumor implantation. Images were first acquired with ¹⁸F-FDG 0.5 hours after injection. Mice were then injected with ⁶⁴Cu-liposomes and imaged at 6, 18, 24, and 48 hours after injection. B: The second cohort (n = 16 mice) was imaged 21 days after tumor implantation with ultrasound and then with ¹⁸F-FDG at 0.5 hours after injection. Subgroups of 4 mice were then sacrificed at each imaging time point: 0.5 hours after ¹⁸F-FDG injection (without PET imaging), 6, 24, and 48 hours after ⁶⁴Cu-liposome injection (with ¹⁸F-FDG and ⁶⁴Cu-liposome PET imaging). TI = Tumor Implantation.