Table 1.
Cohort Characteristics by Quartiles of Mid-life Forced Expiratory Volume in 1 Second / Height2: AGES-Reykjavik Study
| General characteristics | Forced Expiratory Volume in 1 second / Height2a |
Pb | |||
|---|---|---|---|---|---|
| 1st Quartile (low) 2nd Quartile 3rd Quartile 4th Quartile (high) | |||||
| N=919 | N=917 | N=912 | N=917 | ||
| Mid-life variables,cM (SD) | |||||
| Age at 1st pulmonary assess. | 54.2 (5.6) | 53.2 (5.4) | 52.1 (5.2) | 49.7 (5.2) | <.0001 |
| BMI | 25.3 (4.0) | 25.5 (3.7) | 25.4 (3.5) | 243.9 (3.4) | 0.21 |
| FEV1/Height2 | 0.77 (0.12) | 0.95 (0.09) | 1.07 (0.09) | 1.24 (0.12) | - |
| Past physical activity, % | 26.4 | 30.2 | 35.3 | 36.1 | 0.00002 |
| Occupation Class, % | |||||
| Manual work | 57.9 | 55.4 | 56.6 | 55.2 | 0.30 |
| Intermediate | 30.0 | 31.2 | 27.9 | 29.5 | |
| Professional | 12.1 | 13.4 | 15.5 | 15.3 | |
| Late-life variables,d M (SD) | |||||
| Age | 77.6 (5.2) | 76.8 (5.2) | 76.0 (5.2) | 74.4 (5.0) | <.0001 |
| Men, % | 32.7 | 32.8 | 32.8 | 32.7 | - |
| Higher education, % | 21.3 | 24.1 | 27.3 | 30.2 | 0.0001 |
| Ever smoker, % | 64.6 | 55.9 | 51.2 | 51.1 | <.0001 |
| Height | 165.2 (9.1) | 165.7 (9.3) | 166.1 (9.1) | 166.2 (9.0) | 0.16 |
| Weight | 73.5 (14.9) | 75.1 (14.5) | 75.9 (14.4) | 75.2 (14.3) | 0.30 |
| Depression (GDS >=6), % | 9.0 | 5.6 | 6.4 | 6.3 | 0.03 |
| Previous CHD, % | 23.0 | 20.8 | 18.6 | 17.5 | 0.02 |
| COPD, % | 6.6 | 3.7 | 1.8 | 2.0 | <.0001 |
| Diabetes, % | 12.8 | 10.9 | 11.4 | 8.2 | 0.01 |
| High Blood Pressure, % | 85.4 | 83.0 | 81.0 | 74.4 | <.0001 |
| Coronary Artery Calciume | 737 (1019) | 643 (987) | 621 (1011) | 561 (991) | 0.37 |
| APOE 4 carrier, % | 26.4 | 27.0 | 27.5 | 29.2 | 0.57 |
| Cognition, M (SD) | |||||
| Memory f | −0.22 (0.95) | −0.07 (0.98) | 0.07 (0.99) | 0.22 (1.01) | 0.0002 |
| Speed f | −0.25 (1.11) | −0.08 (1.04) | 0.09 (0.92) | 0.24 (0.85) | <.0001 |
| Working f | −0.19 (1.02) | −0.11 (0.99) | 0.07 (0.97) | 0.23 (0.95) | <.0001 |
| Cognitive status, % | |||||
| MCI | 10.6 | 8.9 | 7.5 | 4.6 | 0.0006 |
| Dementia | 5.6 | 4.4 | 2.1 | 1.9 | |
Abbreviations: BMI: Body Mass Index: [Weight (in kgs) / Height2 (in meters)]; M (SD): Mean (Standard Deviation); GDS: Geriatric Depression Scale; CHD Coronary Heart Disease; COPD: Chronic Obstructive Pulmonary Disease.
a
Sex specific quartiles.
b
Analysis of variance or multinomial logistic regression adjusted for sex by virtue of sex-specific quartiles of FEV1 and age.
c
Measured at the time of the first spirometry;
d
Measured at the time of cognitive assessment;
e
Agatston score;
f
Demented and MCI subjects not included (n=416).