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. Author manuscript; available in PMC: 2013 Aug 3.
Published in final edited form as: J Mol Biol. 2012 May 10;421(1):54–66. doi: 10.1016/j.jmb.2012.05.008

Fig. 3.

Fig. 3

The comparison of cooperativity of calcium activation of the thin filament measured with R-IVM experiments26 and flexibility of TNT1 measured from our simulations shows a correlation between the two properties (r=−0.94). The flexibility of TNT1 was calculated by measuring the variance (σ2) of the rgyr of residues 70–170 of cTnT. The broken line is a best-fit line to highlight the inverse nature of the relationship between flexibility and cooperativity. Data are provided in Supporting Information, “rgyr and R-IVM data”.