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. 2012 Oct 31;109(2):507–517. doi: 10.1152/jn.00726.2012

Fig. 7.

Fig. 7.

In TRPV1+ neurons, ST and focal shocks evoked both synchronous EPSCs, as well as asynchronous EPSCs in proportion to afferent activation. A: the basal level of sEPSCs was defined as the 1-s period before stimulation. ST and focal shocks (50 Hz, arrowheads) evoked large synchronous EPSCs. Gabazine (3 μM) was present throughout. The rate of asynchronous EPSCs was calculated as the EPSC frequency greater than basal following shocks. Asynchronous release increased after activation of both ST and focal shocks (6 traces overlaid, shock artifacts blanked). B: analysis of A showed that asynchronous EPSC frequency following shock bursts (arrowheads) and combined shocks increased release rates over ST and or focal shocks alone (100-ms bins). C: across cells (n = 4), basal EPSC frequency remained constant between tests (hashed bars). Asynchronous release (net EPSC frequency greater than basal for 1 s following shocks) with ST and focal shock bursts was greater than ST or focal shocks alone. *P < 0.05, one-way ANOVA with repeated measures.