Table 3. Expression levles of the seven miRNAs and their diagnostic significace in sputum of 36 lung adenocarcinoma patients and 36 healthy controls.

MiRNA	Mean (SD) in cancer patients	Mean (SD) in healthy controls	P*	AUC* (SE)	Cutoffs	Sensitivity (%)	Specificity (%)
MiR-486	0.051 (0.034)	0.182 (0.167)	<0.001	0.834 (0.034)	0.108	66.9	79.4
MiR-126	0.083 (0.087)	0.258 (0.198)	<0.001	0.824 (0.032)	0.156	67.2	73.8
MiR-145	0.132 (0.073)	0.351 (0.297)	<0.001	0.807 (0.031)	0.226	59.5	82.9
MiR-21	8.217 (5.680)	2.730 (2.354)	<0.001	0.846 (0.038)	5.664	72.6	79.2
MiR-182	7.463 (5.822)	2.212 (1.164)	<0.001	0.825 (0.033)	4.973	64.3	79.5
MiR-200b	6.623 (5.367)	2.931 (1.285)	<0.001	0.823 (0.036)	4.838	62.9	78.5
MiR-375	7.207 (6.012)	2.894 (1.766)	<0.001	0.822 (0.035)	5.267	63.9	80.6

Abbreviations: AUC, the area under receiver operating characteristic curve; SD, standard deviation; SE, standard error.

^*Both the P value and AUC were obtained using the U6-normalized values