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The role of miR-124a in neuronal development and its regulation by REST. The upregulation of miR-124a expression during neuronal differentiation requires the derepression by the REST-SCP1 complex. As the most abundant miRNA in the brain, miR-124a regulates the expression of many target mRNAs. Yet, the developmental consequences of lack of miR-124a in vivo remain to be further examined.
