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A negative feedback loop between an miRNA and a transcription factor in Drosophila. (a) In progenitor cells in the Drosophila eye, high-level expression of the transcription factor Yan suppresses miR-7 expression. (b) During photoreceptor differentiation, transient activation of the epidermal growth factor receptor (EGFR) signaling pathway leads to the degradation of Yan and the expression of miR-7, which further downregulates the level of Yan through binding to its 3′ UTRs.
