Table 1.

Proteins affecting the expression levels of Nrf2

Proteins increasing Nrf2 accumulation			Proteins decreasing Nrf2 accumulation
Protein	Function	Ref.	Protein	Function	Ref.
p21	154KRR motif in p21 directly interacts with the 29DLG and 79ETGE motifs in Nrf2	77	INrf2/Keap1	Facilitates Cul3-Rbx1-mediated ubiquitination of Nrf2 via Neh2 domain of Nrf2	8, 10, 41–44
p62	Sequesters Keap1 into aggregates	89, 90	Bach1	Inhibits binding of Nrf2 to ARE	45
PKCδ	Phosphorylates Nrf2 at S40 and releases Nrf2 from INrf2	7	Src-A subfamily kinases	Phosphorylates Nrf2 at Y568, triggering its nuclear export and degradation	46, 47
PALB2	Direct interaction between the ETGE motif of PALB2 and the Kelch domain of INrf2/Keap1	78	GSK3β	Directly phosphorylates a cluster of serines in the ETGE domain of Nrf2, targeting it for degradation by SCFβTrCP; indirect via Src-A subfamily kinases	79, 47
K-Ras, B-Raf, and Myc	Increase Nrf2 transcription and basal expression	81	SCF/β-TrCP	Adaptor protein for Skp1-Cul1-Rbx1-mediated ubiquitination of Nrf2 via Neh6 domain of Nrf2	79