Figure 4.

Topical application of bimatoprost promoted hair growth in mice in vivo. Bimatoprost applied topically to female mice for 2 wk stimulated resting (telogen) follicles to start to grow i.e., enter the next hair cycle (anagen). Pink skin visible in d 0 photographs confirms telogen status. Growing hairs are initially seen as darkening skin until black hair projects outside the skin (as seen in sequential photographs of individual animals). Bimatoprost (Bim) at 0.03, 0.10, and 0.30% significantly (P<0.001) advanced the first day at which anagen was visible, compared to the vehicle alone (top graph) and increased the percentage of animals in which all follicles on the back had grown at d 42 (bottom graph). n = 10/treatment. ***p < 0.001 vs. control.