Table 1.
Characteristics of PTU- and MMI-treated embryos
| Characteristic | Vehicle | MMI (1 mM) | PTU (1 mM) |
|---|---|---|---|
| Mortality (%) | 2.2 | 3.1 | 3.8 |
| Stunted larvae (%) | 0.3 | 1.8 | 24.2* |
| Heart defects (%) | 0.7 | 3.9 | 43.7* |
| l-loop | 0.0 | 1.4 | 24.0* |
| Undefined | 0.7 | 2.5 | 19.7* |
| Gut defects (%) | 2.8 | 6.2 | 100* |
| Miscoiled | 2.8 | 4.8 | 88.9* |
| Uncoiled linear | 0.0 | 0.7 | 11.1* |
| Situs inversus | 0.0 | 0.7 | 0 |
| Pigmentation | Normal | Normal | Decreased |
| Edema (%) | |||
| Cardiac | 0.7 | 3.7 | 23.2 |
| Abdominal | 0.7 | 2.3 | 22.7 |
| Facial | 0.7 | 5.1 | 5.4 |
| Optic | 0.7 | 3.4 | 6.5 |
| Length (mm) | 5.28 ± 0.22 | 5.17 ± 0.52 | 2.64 ± 0.38* |
| Embryos scored (n) | 212 | 196 | 122 |
| Total embryos (n) | 218 | 205 | 164 |
| Experiments (n) | 3 | 3 | 3 |
Note that one embryo can have different malformations. All malformations were scored and counted individually. Length values are means ± sd.
*
P < 0.001; 1-way ANOVA.