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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Aug 23;1832(1):11–19. doi: 10.1016/j.bbadis.2012.08.011

Fig. 1. Schematic of IL-12 family cytokines and receptors.

Fig. 1

IL-12 family cytokines are heterodimers composed of shared alpha and beta chain subunits that dimerize to form IL-27, IL-35, IL-12, and IL-23. Each cytokine signals through unique heterodimeric cell surface receptors. Receptor composition for the newest member of the family, IL-35, has not been determined.