Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Complementary product selectivities of wildtype and mutant EZH2 underlie the hyper-trimethylation phenotype among heterozygotes. Wildtype EZH2, a subunit of PRC2, monomethylates and dimethylates H3K27. Mutant EZH2 (Y641F/N/S/H), with its product selectivity shifted to higher-order methylation products, has the capacity to form H3K27Me3.
